Things to know before PRP therapy

Things To Know Before Going For PRP Therapy

Category: Blog

“I was a former national cyclist, and athlete. I have worked out my entire life and I reached a point where I couldn’t do any of that. My friend knew about this process and suggested this to me. I had my knees done, my hips, my elbows, and my shoulders were done. It’s been a month now and I feel probably 20 years younger now.”

John Michaels seemed relieved when he gave this testimonial after receiving PRP therapy in Philadephia from Regen America.

You go to and from searching for relief for your knee pain, or for pain in any other part of the body. PRP Therapy can be the ultimate solution to all your woes.

Read more about the effectiveness of PRP Therapy in Breaking the Code: PRP (Platelet-Rich Plasma) Therapy & its Effectiveness.

So what does a PRP Therapy professional do to help you get relief from your pain?

A surgery? No!

Go through any testimonial and you will notice one thing that Regen America’s PRP therapy in Philadelphia is done without having to resort to surgery.

Today, we are going to enlighten you on the various aspects of PRP therapy and also show you how the procedure is carried out.

Before hopping into the basis of how is it done, you must first know the precautions that need to be taken before going for the treatment.

The below guidelines have been devised by professionals who excel in this field and any doctor practicing PRP therapy in Philadelphia will advise patients of the following guidelines:

  • Avoid any medications for 2 to 3 weeks into the procedure.
  • Also, one must stop taking non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin or ibuprofen, or any arthritis medications a week preceding to the procedure.
  • Avoid any kind of anticoagulation medication for 5 days before the procedure.
  • The day before the procedure you must drink plenty of fluids to avoid any issues in the pre-procedure examination.
  • Some people may require anti-anxiety medication immediately before the procedure begins. So, be ready for that. Just in case!

What Is in a Platelet-Rich Plasma Injection?

PRP injections are an outpatient procedure as the patient’s own blood is drawn and prepared for injection.

Although, all PRP injections are not the same. The exact preparation of platelet-rich plasma depends on several factors which include

  • the concentration of platelets
  • the concentration of white blood cells
  • the use of additives

The concentration of platelets:

Normal human blood has 150,000 to 450,000 platelets per microliter (μL).
The concentration of platelets in platelet-rich plasma can vary from 2.5 to 9 times of that.

The concentration levels depend on

  • the individual’s blood
  • how much blood was drawn
  • how the centrifuge process was done (e.g., the rotation speed and duration), and other clinical preparation methods.

Now answer a logical question!

Which one do you think will give better results – Plasma with the highest possible platelet concentration or plasma with a lower platelet concentration?

Logically, people may feel the former to be more effective, but this is not the case here.

A lab study suggested that plasma with concentrations 2.5 times higher than normal blood is ideal. Higher concentrations may limit the growth of new cells.

White blood cell count:

  • White blood cells are the components designated to fight infection and keep the immune system safe.
  • Hence, the white blood cells become an important factor here, due to their portentous ability to heal, promoting inflammation, scar tissue, and limiting the damage to nearby tissues.
  • The concentration of white blood cells is also determined by an individual’s blood and its clinical preparation methods.


  • Some doctors practice mixing additives into the platelet-rich plasma. These additives have the power to activate the platelets, stimulate clotting, and this may even enhance platelet-rich plasma’s regenerative properties.

Platelet-Rich Plasma – The procedure (Step-by-step)

Step 1

Blood is extracted from a vein in the patient’s arm and placed into a vial. Don’t worry as the blood they extract will be between 15 to 50 mL or less than 2 ounces.

Step 2

The blood is then processed using a centrifuge machine. The task of preparing the centrifuged platelet-rich plasma for injection is done by a doctor or technician.

Step 3

Before injecting, the affected joint area is cleansed with a disinfectant such as alcohol or iodine.

Step 4

In case ultrasound is being used, a special gel is applied to an area of skin near the injection site.

Step 5

An ultrasound probe is then pressed against the skin covered with gel. A live image of the joint will be projected onscreen to assist the doctors.

Step 6

The patient is then asked to relax to facilitate the injection. This will also make the injection less painful.

Step 7

The doctor injects a small amount of platelet-rich plasma into the joint capsule using a syringe and a needle.

Step 8

The area where the PRP has been injected is then cleaned and bandaged.

The platelet-rich plasma stimulates a series of biological responses, and the injection site may remain swollen and painful for about 3 to 4 days.

After the PRP Injection: Immediate Follow-up Care

Patients must take special care for a few days after the therapy and avoid putting a strain on the affected part.

The most common suggestions from doctors to patients are:

  • Avoid any anti-inflammatory pain medication. In some cases, doctors may provide other pain medications.
  • The affected joint has to be kept protected and immobilized and patients who receive an injection at the ankle, knee, or hip may be advised to use crutches.
  • You have to use a cold compress a few times a day for 10 to 20 minutes at a time. This will help decrease post-injection pain and swelling.
  • Patients who have jobs that drain them physically can go back to work the next day.
  • Resume normal activities when swelling and pain decreases. Normally these decrease in a few days.

Questions to ask

Albert Einstein once said denoting the importance of questioning and that one must never stop asking questions.

Likewise, questions must also be asked when searching for the right physician for getting PRP therapy done.

We have jotted down a list of questions that you can go with while visiting one!

1. How do you diagnose and assess the problem?

See that the diagnosis is verified with imaging technology, whenever PRP therapy is being performed.
In addition to this, the doctor must examine if the condition is too serious or not be treated with PRP therapy.

2. What training do you have to go through to perform PRP injections?

Avoid a physician who has neither participated in a formal training course nor had any extensive one-on-one training with an experienced doctor. This has been recommended by The International Cellular Medicine Society.

3. Do you use ultrasound, fluoroscopy, or computed tomography (CT) scan to guide injections?

Imaging technologies can be used to ensure that the injections are made precisely to the joint capsule which needs the therapy.

4. What is your experience and success rate for treating conditions with PRP injections?

PRP injections are useful in treating a number of different joint conditions and you must confirm that the physician is familiar with using PRP specifically for treating your condition.


The doctors also have a duty to explain certain things to the patients before administering platelet-rich plasma injections:

1. Potential risks involved
2. Viable benefits
3. Steps to be carried out in the procedure
4. Follow-up protocol
5. The expense of the procedure

Some doctors also may make you sign an informed consent form which states that you understand that platelet-rich plasma therapy is an elective procedure and that certain risks and side effects exist and you are fully aware of that.

PRP therapy in Philadelphia is now getting widely accepted in various fields.
PRP therapy might not be cheap sometimes, but PRP injections have become super popular. Even elite athletes have gravitated to this gem of a treatment. It acts as the perfect option for injuries in the knee or other parts of the body.

PRP therapy in Philadelphia is performed by PRP treatment experts in Regen America for various health problems. Our experts are certified and experienced in discovering what every patient needs depending on their conditions. Regen America has a team of professionals who conduct a complete medical examination and medical history to ensure that you are the right candidate for PRP treatment. Contact us now to learn more about us and our services!

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