Bone Marrow-Derived MSCs In Elderly

Bone Marrow-Derived MSCs In Elderly

April 04, 2019

Commonly found in the bone marrow, mesenchymal stem cells (MSCs) are multipotent stromal cells. They have the potential to differentiate themselves to a variety of cell types. Moreover, they can also be isolated from other tissues present in the cord blood, peripheral blood, fallopian tube, fetal liver, and lungs.

MSCs play an important for making and repairing skeletal tissues, such as cartilage, bone and the fat found in bone marrow.

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Usually, as people age, the renewal ability of MSCs deteriorate and their property to differentiate into cells also decreases.

Keeping this in mind, we at Regen America have featured the views of Dr. Philippe Hernigou, Chief of Orthopedic Surgery, Henri Mondor Hospital. The article contains Dr. Philippe’s insights derived after an extensive study of 31 years regarding bone marrow. So, let us get into it:

There has been a controversy saying that one loses mesenchymal stem cell [MSC] version of bone marrow cells with age. It is also believed that as people age, the cell’s storage keeps decreasing.

The referred fact is true to an extent, but there are certain exceptions. Moreover, a lot of hype also been created regarding the MSC content in the aging bone marrow to sell amniotic fluid-containing products, especially from the ones who are selling it.

Let’s understand how-

The author’s opinion

• FDA approval – There is no clear status about these products being approved by the Food and Drug Administration (FDA). The drugs that are not approved by the FDA do not qualify for sales.
• Evidence – There are no reports published that profess the clinical efficacy of such drugs.
  There has been a sales strategy to illegally sell the products.

Another view that comes into the picture is the fuzzball view. So, what is a fuzzball view?

Fuzzball view – Another view that is prevalent is that of making a fuzzball out of a person’s fat for treating the ailments as an alternative for MSCs.

Even after a systematic approach and perfectly following the rules, people may succeed in their fuzz ball approach, but their products won’t be eligible for treating orthopedic pathologies.

So, for an autologous treatment, a person is left with two options –PRP and BMC.

Considering that you want a therapy that is based on stem cells, the best option is to go with Bone Marrow Aspirate Concentrate (BMC or BMAC). The therapy is quite effective regenerative therapy and accelerates the healing process. Similar to a PRP treatment, the BMC also utilizes technology to harness the cells of the patients, but under a BMC treatment, the cells are taken directly from the bone marrow.

If one wants a therapy that consists of a useful level of stem cells, BMC is the way to go.

However, people are misled by a group of sales representatives claiming that there are no MSCs in aged people. Which is in fact, not true.

Below are some insights derived from the “Utility of BMC Therapy in the Elderly—How Do Changes in MSC Concentration Affect Outcome?” presented at the ASIPP conference-

As per Dr. Hernigou, the frequency of MSC in bone marrow is 1 MSC per 250,000 nucleated cells.

So, to begin with, the fat tissue is the prime consideration for an MSC-based therapy.

Moreover, the absolute number of MSCs found in BMC depends on the number of nucleated cells present in the bone marrow, which are quite high in BMC.

So, as Dr. Hernigou pointed out, despite the lower frequency of MSCs in bone marrow, there are huge numbers of nucleated cells, which means that BMC has sufficient MSCs to be therapeutically beneficial, even in the elderly. A rigorous study of 31 years done by Dr. Hernigou supports the theory.

He placed the MSC content on a y-axis against age on the x-axis.

And after working out the data set, he derived that the MSCs for the elderly are present in different parts of the body. In this case, it was concluded that the average 80-year-old had more than 500 MSCs per mL of bone marrow in their iliac crest.

However, the number is not too low and not substantiallybetter than having
“no MSCs” in the bone marrow.

Comparatively, an average 15-year-old person had about 3,000 MSCs per mL of bone marrow.

Moreover, there is no doubt in the fact that the hawkers of fat tissue-derived MSC preparations and amniotic fluid products will be lowered down by Dr. Hernigou’s data.

But we are quite sure that convincing physicians will be quite challenging for the hawkers, especially when Dr. Hernigou publishes his ‘MSC bone marrow data in the elderly’, backed by a couple of clinical studies and experiments using the elderly’s BMC to treat diseases, like rotator cuff tears and severe osteoarthritis.

However, there was not sufficient information on clinical study data regarding Dr. Hernigou’s review on MSC bone marrow data in the elderly, the aforementioned highlights make it clear that the MSCs in the bone marrow of elderly people is absent is not true.

We, at Regen America, do not believe in painkillers and invasive surgery. With a motive to assist patients in healing their diseases in the most natural way, we offer stem cell-based regenerative therapies. If you also believe in leading a fuller life with the help of natural therapies to cure your diseases, contact us today!